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June 15, 2018

Controversy continues to swirl around the benefits and risks associated with hormone-replacement therapy (HRT). Although experts and guidelines support short-term use of HRT to treat unwanted menopausal symptoms, clinicians and scientists are often confused by how HRT...

May 18, 2018

Evidence suggests that oestrogen has both protective and damaging effects in the body. Circulating oestrogens are transported in the blood as inactive forms, as they are bound to sulphates. These sulphate groups must be removed to activate these oestrogens and this is...

November 25, 2015

Mutations in the tumour suppressor phosphatise and tensin homolog (PTEN) result in Cowden syndrome, a rare autosomal dominant inherited disorder characterised by multiple tumour-like growths called hamartomas and an increased risk of developing hormone-dependent cancer...

July 26, 2015

Prostate cancer is driven by androgens, particularly 5alpha-dihydrotestosterone (5alpha-DHT). Therapeutic options include systemic androgen deprivation therapy to limit 5alpha-DHT availability. However, many prostate tumours develop resistance to this line of therapy a...

March 31, 2015

Ingestion of marijuana is known to cause an uncontrollable urge to eat, known as ‘the munchies’. A recent study by Koch and co-workers demonstrates that this drive is controlled by pro-opiomelanocortin (POMC)-producing neurons found in the hypothalamus. All previous ev...

August 12, 2014

Familial gluocorticoid deficiency (FGD) is a rare, hereditary form of adrenal insufficiency characterised by resistance of the adrenal glands to stimulation by their trophic hormone, ACTH (adrenocoticotropic hormone). FGD patients typically present in infancy or early...

January 28, 2014

New research (see it here) has shown that the anti-oestrogens raloxifene and gonadorelin block the formation of colorectal tumours in female mice genetically pre-disposed (so called ApcMin/+ mice) to develop colorectal cancer. Anti-oestrogens inhibited tumour formation...

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Anti-oestrogens inhibit colorectal tumourigenesis

January 28, 2014

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